Professor Dr. Miroslav Cervinka CV
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Professor Miroslav Cervinka, MD, PhD
ORPHEUS President
(EC member 2010-) ( President 2014-)
Department of Medical Biology and Genetics, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Simkova 870, 50038 Hradec Kralove, Czech Republic
Place and date of birth: Brno, Czech Republic, May 24, 1950
Degrees and professional qualifications:
1973 M.Sc. Physiology of animals, Faculty of Sciences, Charles University Prague,
1975 Rerum Naturalium Doctor, Faculty of Sciences, Charles University Prague,
1980 Scientarum Candidatus CSc. (corresponding to "PhD") in General Biology
1984 Medicine Universae Doctor (MD), Faculty of Medicine in Hradec Kralove
1989 Associated Professor in General Biology
2000 Professor in Histology and Embryology
Training:
1968 -1973 Charles University in Prague, Faculty of Sciences, Physiology of Animals
1973 - 1975 Postgraduate studies, Charles University in Prague, Faculty of Sciences,
1978 -1984 General Medicine at Faculty of Medicine in Hradec Kralove
Study visits:
1984 -1985: Department of Biology, Medical Faculty, Erasmus University, Rotterdam, The Netherlands - methods of molecular biology
1990: Department of Human Morphology, Faculty of Medicine Nottingham, toxicity assessment in vitro
1995: Institut für Zellbiologie und Neurowissenschaften Goethe Universität Frankfurt, Frankfurt am Main
Substantive appointments:
1975 - 1990 Research worker - Charles University, Faculty of Medicine in Hradec Kralove, Department of Biology
1975 - 1990 Associate professor - Charles University, Faculty of Medicine in Hradec Kralove, Department of Biology
2000 - till now Professor - Charles University, Faculty of Medicine in Hradec Kralove, Department of Biology
Other appointments:
1990 - till now: Vice Dean for Research and PhD study, Charles University, Faculty of Medicine in Hradec Kralové
1990 - till now member of the Scientific Board of the Faculty of Medicine in Hradec Kralove
1992 - 2002 member of the Scientific Board of the Faculty of Pharmacy in Hradec Kralove
1992 - till now member of the Scientific Board of the Faculty of Military Medicine in Hradec Kralove
1995 - till now member of the Scientific Board of the Charles University
1995 -till now member of the of the international journal ATLA (Alternatives to laboratory animals)
2000 - till now member of the Editorial Board of the international journal ALTEX (Switzerland)
2005 Member of the Scientific Board of the World congress about Alternatives, Berlin
Organizer (president of Organising and Scientific Committee) of the International Congress Cytokinematics (in 1996, 2000, 2004, 2006, 2009)
Membership of scientific societies etc.:
European Society for In vitro Toxicity
ECOPA - European consensus platform
Czecho-Slovak Biological Society
Czech Physiological Society
Awards:
1996 - jubilee medal of the Charles University
1995 - jubilee medal of the Faculty of Medicine
2000 - memorial medal of the Military Medical Academy in Hradec Kralove
Selected recent publications:
Cervinka, M. The Role of Time-Lapse Fluorescent Microscopy in the Characterization of Toxic Effects in Cell Populations Cultivated In Vitro.Toxicology in Vitro 2008,22 (5), 1382-1386.
Červinka, M., Cerman, J., Rudolf, E. Apoptosis in Hep2 cells treated with etoposide and colchicine. Cancer Detection and Prevention, 2004, 28, (3), 214-226.
Červinka, M., Červinková, Z., Rudolf, E. The role of time-lapse fluorescent microscopy in the characterization of toxic effects in cell populations cultivated in vitro. Toxicology in Vitro, 2008, 22, (5), 1382-1386.
Červinková, Z., Lotková, H., Křiváková, P., Roušar, T., Kučera, O., Tichý, L., Červinka, M., Drahota, Z. Evaluation of mitochondrial function in isolated rat hepatocytes and mitochondria during oxidative stres ATLA-Alternatives to Laboratory Animals, 2007, 35, (3), 353-361.
Cervinkova, Z., P. Krivakova, et al. Mechanisms participating in oxidative damage of isolated rat hepatocytes. Archives of Toxicology, 2009, 83(4): 363-372.
Holasová, Š., Mojžíšek, M., Bunček, M., Vokurková, D., Radilová, H., Šafářová, M., Červinka, M., Haluza, R. Cholesterol conjugated oligonucleotide and LNA: A comparison of cellular and nuclear uptake by Hep2 cells enhanced by Streptolysin-O. Molecular and Cellular Biochemistry, 2005, 276, (1-2), 61-69.
Kiss, K., Kiss, J., Rudolf, E., Červinka, M., Szeberényi, J. Sodium salicylate inhibits NF-kapaB and induces apoptosis in PC12 cells. Journal of Biochemical and Biophysical Methods, 2004, 61, (1-2), 229-240.
Rudolf, E., Andělová, H., Červinka, M. Polyphenolic coumpounds in chemoprevention of colon cancer targets and signaling pathways. Anti-Cancer Agents in Medicinal Chemistry, 2007, 7, (6), 559-575.
Rudolf, E., Červinka, M. The Role of Biomembranes in Chromium (III)-induced Toxicity In Vitro. ATLA-Alternatives to Laboratory Animals, 2005, 33, (3), 249-259.
Rudolf, E., Červinka, M. The role of intracellular zinc in chromium(VI)-induced oxidative stress, DNA damage and apoptosis. Chemico-Biological Interactions, 2006, 162, (3), 212-227.
Rudolf, E., Červinka, M., Cerman, J. Zinc has ambiguous effects on chromium (VI)-induced oxidative stress and apoptosis. Journal of Trace Elements in Medicine and Biology, 2005, 18, (3), 251-260.
Rudolf, E., Červinka, M., Cerman, J., Schröterová, L. Hexavalent chromium disrupts the actin cytoskeleton and induces mitochondria-dependent apoptosis in human dermal fibroplasts. Toxicology in Vitro, 2005, 19, (6), 713-723.
Rudolf, E., Králová, V., Červinka, M. Selenium and colon cancer - from chemoprevention to new treatment modality. Anti-Cancer Agents in Medicinal Chemistry, 2008, 8, (6), 598-602.
Rudolf, E., Radocha, J., Červinka, M., Cerman, J. Combined effect of socium selenite and campthotecin on cervical carcinoma cells. Neoplasma, 2004, 51, (2), 127-135.
Rudolf, E., Rudolf, K., Červinka, M. Selenium activates p53 and p38 pathways and induces caspase-independent cell death in cervical cancer cells. Cell Biology and Toxicology, 2008, 24, (2), 123-141.
Rudolf, E., Rudolf, K., Červinka, M. Zinc induced apoptosis in HEP-2 cancer cells: The role of oxidative stress and mitochondria. BioFactors, 2005, 23, (2), 107-120.
Rudolf, E. and M. Červinka The role of intracellular zinc in chromium(VI)-induced oxidative stress, DNA damage and apoptosis. Chemico-Biological Interactions, 2006, 162 (3): 212-227.
Rudolf, E. and M. Cervinka Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts.Toxicology Letters, 2009, 188 (3): 236-242.