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Paola Zanovello CV

PAOLA ZANOVELLO

Professor of Immunology

School of Medicine, Department of Surgery, Oncology and Gastroenterology

University of Padova, Padova, Italy
e-mail address: paola.zanovello@unipd.it

 

DATE & PLACE OF BIRTH : July 2, 1952, Padova, Italy

Married, 1 daughter

PRESENT ADDRESS: Via Dell’Arco, 16, I-35128, Padova, Italy

EDUCATION and Training:
1975
Degree in Biological Sciences at the University of Padova
1975-1980 Post-graduate Fellow, Institute of Oncology, University of Padova

 

PROFESSIONAL RESEARCH APPOINTMENTS:
1981-1991 Researcher, Institute of Oncology, University of Padova
1992-2009 Associate Professor of Immunology, Department of Oncology and Surgical Sciences, University of Padova

2003 Visiting Fellow (American-Italian Cancer Foundation) at NIH, Bethesda, MD

2010- Professor of Immunology, University of Padova

ACADEMIC AND SCIENTIFIC COMMITTMENTS:

Member of the Scientific Committee of the School of Medicine.

Member of the Ethical Committee of the Veneto Institute of Oncology.

Director of the PhD Course in Oncology and Surgical Oncology, University of Padova

Chairman of the Doctoral Committee of the University of Padova

Member of the Committee for the evaluation of didactic activity at the University of Padova

Member of the Scientific Committee of Italian Association for Cancer Research (AIRC)

MEMBERSHIP OF SCIENTIFIC SOCIETIES

American Association of Immunologists

Italian Society of Immunology, Clinical Immunology & Allergology

Italian Cancer Society

Italian Network for Biotherapy in cancer

REFEREE FOR INTERNATIONAL JOURNALS

Journal of Immunology

European Journal of Immunology

Immunology Letters

Cancer Research

Clinical Immunology and Immunopathology

Blood

International Journal of Cancer

OTHER ACADEMIC AND SCIENTIFIC ACTIVITIES

Member of the Didactic committee of the School of Medicine

Tutor of medical students during their internship

Supervisor of 10 PhD students

External examiner for PhD theses

 

 

RESEARCH ACTIVITIES:
Tumor Immunology with a special attention to immune responses mediated by tumor-specific cytotoxic T lymphocytes, and mechanisms underlying their modulation. More recently, the relationships between tumor and microenvironment, and new treatments able to interfere with immunosuppressive mechanisms.

Scientific Publications: 295, of which 114 published in peer-reviewed journals.

 

Selected publications (2009-2013)

  1. Tosello, V., Zamarchi, R., Merlo, A., Gorza, M., Piovan E., Mandruzzato, S., Bronte, V., Wang, X., Ferrone, S., Amadori, A., Zanovello, P.: Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-alpha or IL-4. Eur J Immunol, 39, 56-66, 2009
  2. Mandruzzato, S., Solito, S., Falisi, E., Francescato, S., Chiarion-Sileni, V., Mocellin, S., Zanon, A., Rossi, C.R., Nitti, D., Bronte, V., Zanovello, P.: IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients. J Immunol, 182, 6562-6568, 2009
  3. Bobisse, S., Rondina, M., Merlo, A., Tisato, V., Mandruzzato, S., Amendola, M., Naldini, L., Willemsen, R.A., Debets, R., Zanovello, P ., Rosato, A: Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors. Cancer Res, 69, 9385-9394, 2009
  4. Ugel, S., Scarselli, E., Iezzi, M., Mennuni, C., Pannellini, T., Calvaruso, F., Cipriani, B., De Palma, R., Ricci-Vitiani, L., Peranzoni, E., Musiani, P., Zanovello, P., Bronte, V.: Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes. Blood, 115, 1374-1384, 2010
  5. Peranzoni, E., Zilio, S., Marigo, I., Dolcetti, L., Zanovello, P., Mandruzzato, S., Bronte, V.: Myeloid-derived suppressor cell heterogeneity and subset definition. Curr Opin Immunol, 22, 238-244, 2010
  6. Marigo, I., Bosio, E., Solito, S., Mesa, C., Fernandez, A., Dolcetti, L., Ugel, S., Sonda, N., Bicciato, S., Falisi, E., Calabrese, F., Basso, G., Zanovello, P., Cozzi, E., Mandruzzato, S., Bronte, V.. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity, 32, 790-802, 2010
  7. Ruggero, K., Corradin, A., Zanovello, P., Amadori, A., Bronte, V., Ciminale, V., D’Agostino, D.M.: Role of microRNAs in HTLV-1 infection and transformation. Mol Aspects Med, 31, 367-382, 2010
  8. Nardo G, Favaro E, Curtarello M, Moserle L, Zulato E, Persano L, Rossi E, Esposito G, Crescenzi M, Casanovas O, Sattler U, Mueller-Klieser W, Biesalski B, Thews O, Canese R, Iorio E, Zanovello P, Amadori A, Indraccolo S. Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization. Cancer Res, 71, 4214-4225, 2011
  9. Ghisi M, Corradin A, Basso K, Frasson C, Serafin V, Mukherjee S, Mussolin L, Ruggero K, Bonanno L, Guffanti A, De Bellis G, Gerosa G, Stellin G, D’Agostino DM, Basso G, Bronte V, Indraccolo S, Amadori A, Zanovello P. Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150. Blood, 117, 7053-7062 2011
  10. Solito S, Falisi E, Diaz-Montero CM, Doni A, Pinton L, Rosato A, Francescato S, Basso G, Zanovello P, Onicescu G, Garrett-Mayer E, Montero AJ, Bronte V, Mandruzzato S. A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood, 118, 2254-2265 2011
  11. D’Agostino DM, Zanovello P, Watanabe T, Ciminale V. The microRNA regulatory

network in normal- and HTLV-1-transformed T cells. Adv Cancer Res, 113, 45-79,

2012

12. Pizzini S, Bisognin A, Mandruzzato S, Biasiolo M, Facciolli A, Perilli L, Rossi E,

Esposito G, Rugge M, Pilati P, Mocellin S, Nitti D, Bortoluzzi S, Zanovello P. BMC

Genomics 14, 589-603, 2013