Prof. Dr. C.F.H. van Schravendijk
Doctoral School in Life Sciences and Medicine.
Master Program Biomedical Sciences
Cell and Gene Therapy.
Diabetes Research Center
Unit of Protein Biochemistry
Vrije Universiteit Brussel – GF
B1090 Brussels – BELGIUM
1981†† : †† Drs in Mathematics and Natural Sciences;
Biology (cum laude) at the† State University of Leiden. (13.1.’1981)
1986 † : †† Master in Medical and Pharmaceutical Research great distinction) at the† Vrije Universiteit Brussel. (13.6.’1986)
1988†† :††† Philosophy Doctor (PhD) in Biomedical Sciences, Medical and Pharmaceutical Research (summa cum laude) at the Vrije Universiteit Brussel. (3.6.’1988)
-†††† American Association for the Advancement of Science (since 1999).
-†††† Belgian Club of the University Foundation (since 2002)
-†††† Association for Medical Education in Europe (AMEE)
-†††† ORPHEUS ñ Organisation of PhD Education in Biomedicine and Health Sciences in the European System (since 2009).
-†††† European University Association (EUA) ñ As institutional representative (since 2009).
ZAP ñ Full professor (voltijds Hoogleraar) – V.U.B. (since 2005)
Co-ordinator, responsible for the daily management of the Master in Biomedical Sciences ñ Cell and Gene Therapy (former Master Program in Medical and Pharmaceutical Research).
Responsible for the faculty management and co-ordination of the Doctorate in Medical Sciences, since 1994 as coordinator and since 2002 as chairman of the Facultyís committee.
Director of the Doctoral School of Life Sciences and Medicine since 2008-09), with ±235 PhD students.
Faculty deputy in the Universityís central financial committee for education.
Deputy chair† and Facultyís contact person for internationalisation.
First year Bachelorís Medical Doctor: Co-ordinator en teacher of Scientific Thought and Computer Sciences (SP:6). (Computer sciences: M. Nyssen)
First year Bachelorís Biomedical Sciences: Co-ordinator en teacher of Scientific Thought and Computer Sciences (SP:6). (Computer sciences: M. Nyssen)
First year Bachelorís Pharmacy: Co-ordinator en teacher of Scientific Thought and Computer Sciences (SP:6). (Computer sciences: M. Nyssen)
Third year Medical Doctor: Co-ordinator and teacher of the course ìFormulation and defence of a scientific hypothesisî ( SP:4).
This course will also be organised in the third year Bachelorís in Biomedical Sciences
General co-ordination of the Master in Biomedical Sciences: Cell and†††† Gene Therapy.
This is the successor of the former Master in Medical and Pharmaceutical Research under co-ordination of C. van Schravendijk since 1986.††
First and second Master year in Biomedical Sciences: Responsible for content,
organisation and guidance† of the† Medical Seminars (SP:3)
Intermediate year towards the† Master in Nursing and Obstetrics:
Scientific Thought and Computer Sciences (SP:4).
(Computer Sciences: Profs M. Nyssen and R. Vandervelden). These are separate course hours, often taught in the evening.
Teacher and co-ordinator of: “Life Sciences, from basis to guide” (30 uur/j., SP:8). In the Master in Biomedical Sciences ñ Cell and Gene Therapy. This class has recently been extended with 15 hrs of practical training.
In this program, also responsible for co-ordination of: Medical Seminars (30 uur/j., SP: 4), Project preparation (30 uur/j., SP: 4), Seminars, visits and demonstrations (30 uur/j., SP: 3), Journal and dataclubs (60 uur/j., SP7) and the thesis (SP: 20).
Orientation Training (30 h./year ;† coordinator C. Van Schravendijk, SP: 3)
Each ëclassí is able to host students for orientation training.† The student participates for at least 5 full working days. He/she can select the laboratory in which the orientation training was completed as the place in which the research project for the master thesis will be carried out.
Introduction to the Master thesis. 30 h./year ;† coordinator C. Van Schravendijk (SP: 3) Literature search, topic discussions, project proposal† Students are expected to carry out a research project in a laboratory of their choice.
EDUCATIONAL OUTPUT AND CONTRIBUTIONS
Promoter of the following Master thesis works:
Ilse van Droogenbroeck (1993). Study of islet amyloid polypeptide in human pancreatic tissue and isolated human ? cells.
Elena Levchenko (1993). Investigation of proinsulin in isolated human ? cells and human pancreatic extracts.
Xue Hou (1994) A new immunoadsorption method for the measurement of proinsulin conversion intermediates in human islets.
Katleen Hostens (1996). Differences in proinsulin and insulin release from perifused human islets.
Kim Tae Yung Van Uytsel (1999). Biosynthesis of islet amyloid polypeptide by rat pancreatic ? cells .
Xavier Pottier (2000). Study of Islet Amyloid Polypeptide and its Precursorforms in Human Type-2-Diabetic Islet Amyloid: Immunochemical Detection and Mass Analysis of Microdissected Deposits.
?†††††††† Cecilia Borromeo (2001). Tissue Distribution of Islet Amyloidosis in the†† Human Type 2 Diabetic Pancreas.
?†††††††† John Igwe (2004). Expression of the receptor for advanced glycosylation end products (RAGE) in the human and rat endocrine pancreas.
?†††††††† Chunmei Long (2005). Glucose and IGF-1 stimulates proliferation of pancreatic beta cells and decreases their apoptosis via increased AKT/PKB signaling and synthesis of specific proteins.
Publication on educational issues regarding the PhD-degree (in Dutch): ìDoctoreren in de Medische Wetenschappen in Vlaanderenî, verschenen in het door CvS samengestelde Nieuw Tijdschrift† themanummer ìGeneeskunde aan de VUB. Themaís in onderzoek, onderwijs en academisch onderbouwde zorgverstrekkingî (1999-2000).
Organisation of the international symposium: ìCell Therapy ñ Biological Basis and Clinical Applicationsî on 3 and 4 April 2000 in the framework of the interuniversity ìTruncus Communisî for the PhD program in Medical Sciences.
Organisation of the international symposium: ìMolecular Pathology of Protein Aggregation in Cellular Senescenceî organised on 25 April 2002 in the framework of the interuniversity ìTruncus Communisî for the PhD program in Medical Sciences.
Promoter of the PhD thesis in Medical Sciences:† ìProinsulin conversion in precultured islet-? cellsî, defended successfully on 25 June 2002 by Yasmeeni ZAMBRE (co-promotor: Z. Ling).
Co-promoter of the PhD thesis in Medical Sciences: ìRole of Glucagon and glucagon-related peptides in the regulation of insulin releaseî, defended successfully on15 March 2002 by Karin MOENS (promoter: F. Schuit).
Invited lecture in the symposium ìEthical aspects of human and animal experimentationî, organised on 24 October 2002 for the Interuniversity Truncus Communis for the PhD program in Medical Sciences (title of the presentation:î Scientific Fraudî).
Composer and co-editor of the VUB publication: ìGeneeskunde op het raakvlak met cultuur en ethiekî, published in 2002.
Award for ìbest scientific contentî for the project “Focus op Diabetes”, presented in the framework of the “Tweede Festival van de Biomedische Wetenschap” with high school students. The award was received on 27 June 1998 from Z.K.H. Prince Laurent.
Invited seminar on 12 November 2002 in the framework of the Institutional Research Seminars of the Dutch Institute for Brain Research (NIH) in Amsterdam entitled: ìType 2 Diabetes and Molecular Misreadingì.
Promoter of the PhD thesis in Medical Sciences:† ìMolecular and cellular analysis of hormone and incretin signalling in pancreatic beta cell functionî, defended successfully in April 2004 by Dominique DELMEIRE (co-promotor: F. Schuit).
Chair of the international symposium ìInternational Harmonisation of the Bachelor Master System in the Curricula of Medical Doctor and the Biomedical Sciencesî ñ A two-day workshop by the Faculty of Medicine and Pharmacy of the Dutch speaking Brussels Free University. On 20 en 21 May 2005.
Invited lecture at the University of Heidelberg entitled ìExpression of the receptor for advanced glycation end products (RAGE) in human and rat pancreatic islet cells – a role in the pathophysiology of diabetes?î on 22 September 2005.
Invited lecture in the symposium ìEthics in Science ñ A one day course for biomedical scientistsî, organised on 28 October 2005 in the Royal Academy of Medicine in the framework of the interuniversity Truncus Communis for the PhD program in Medical Sciences (Title of the contribution: ìScientific Fraudî).
Invited lecture and workshop chair in the Fifth International Annual Conference of the European Network for Ombudsmen in Higher Education (ENOHE) in Antwerp. Thursday 24, Friday 25 and Saturday 26 May, 2007. Title of the lecture: ìFraud and Plagiarismî.
First author of the MEDINE report ìExploring and Developing Links between Medical Education and Researchî. Report of the MEDINE TaskForce 5 on Medical Education and Research, MEDINE Thematic Network 114063-CP-1-2004-1-UK-ERASMUS-TN. September 14, 2007, Antalya, Turkey. Report printed by VUB.
Chair of the international symposium ìCrossing borders – crossing overî. Switching between (bio)medical curricula and between countries. A two-day workshop by the Faculty of Medicine and Pharmacy of the Dutch speaking Brussels Free University held on 31 May and 1 June 2007.
Publication of a textbook on Scientific Thought in Dutch: ìWetenschappelijk Denken. Een inleiding voor de Medische en Biomedische Wetenschappenî. Acco Uitgeverij-Leuven ñ Belgium, Voorschoten,† Nederland. September 2007, 250 pp.
Invited lecture and workshop, hosted by the University of Wien: Research for medical students – how much (or how little) is appropriate? Graz, Austria September 18 ñ 20, 2008
Invited chair for a workshop organized by the University of Sarajevo on setting up doctoral education in the faculty of Medicine at the University of Sarajevo.† Together with Prof. H. Stockinger, Med. U. Vienna. November 2009.
Country report for Belgium (Flanders) in the 5th Annual Conference of the ORPHEUS network in Vienna, April 2010.
PhD students supervised more recently/currently:
?†††††††† Karen Moens (with prof. F. Schuit). Role of Glucagon and Glucagon-Related Peptides in the Regulation of Insulin Release
?†††††††† Dominique Delmeire (with prof. F. Schuit). Molecular and cellular analysis of incretin signaling in pancreatic beta cell function.
?†††††††† Farah van Genderen (with Prof. F. Gorus). Development of new RIA and TRFIA methods for measurement of hormonal markers relevant for diabetes.
?†††††††† Folefac Aminkeng (with prof. B. Van der Auwera): Genetic risk assessment in type 1 diabetes: genetic and functional studies in Caucasian and Sub-Saharan African populations.
?†††††††† Lei Jiang (with profs. Z. Ling and F. Gorus). New markers in (pre) diabetes.
?†††††††† Milca Asanghanwa Alahkala (with prof. J.C. Mbanya). Diabetes in Cameroon as compared to Belgium: epidemiology, clinical and biological characteristics of recent-onset diabetic patients.
ACADEMIC, Interuniversity and international responsibilities
Co-ordinating member lid of the Interuniversity Steering Party for the PhD in Medical Sciences ñ meeting in the Royal Academy† of Medicine (from 1994 to 2006).
Responsible for the annual publication of the Interuniversity Study Brochure of the PhD in Medical Sciences in Flanders (1994 – 2006, annual edition 1000 copies).
Member and Task Force leader of the international group ìMEDINEî (ìMedical Education in Europeî). Participation in two Task Forces (ìTF on Tuningî and ìTF on Medical Education and Researchî) that investigate the Medical Curriculum (MC) in Europe and prepare recommendations for five aspects regarding the MC in 2007. Supported by the European Community.
Expert member (topic: protein biology) in several PhD juries in Flanders.
Referee of several international peer-reviewed journals in the fields of protein biochemistry and medical education.
Co-promotor and member of the Executive Board of MEDINE2, Erasmus Thematic Network approved for financial support in July 2009. Team leader for Work Package 7 on the ìIntegration of the Research Component in European Medical Educationî (IRCOMED).
University contact for the European University Association (EUA) and its Council for Doctoral Education (CDE).
MAIN PEER REVIEWED RESEARCH OUTPUT (SORTED RETROSPECTIVELY)
?†††††††† van Genderen FT, Gorus FK, Vermeulen I, Vekens EM, De Pauw PE, Pipeleers DG, Van Schravendijk C (2010). Development of a multipurpose time-resolved fluorescence immunoassay for rat insulin. Anal Biochem. 2010 Apr 24. [Epub ahead of print]
?†††††††† Aminkeng F, Van Autreve JE, Weets I, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ; Belgian Diabetes Registry (2009). IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population. Hum Immunol.70(9) : 706-10.
?†††††††† De Pauw PE, Mackin RB, Goubert P, Van Schravendijk C, Gorus FK (2009). Total error profiling of a proinsulin time-resolved fluorescence immunoassay. J Chromatogr B Analyt Technol Biomed Life Sci. 877(23) : 2403-6.
?†††††††† De Pauw PE, Vermeulen I, Ubani OC, Truyen I, Vekens EM, van Genderen FT, De Grijse JW, Pipeleers DG, Van Schravendijk C, Gorus FK (2008). Simultaneous measurement of plasma concentrations of proinsulin and C-peptide and their ratio with a trefoil-type time-resolved fluorescence immunoassay. Clin Chem. 54(12):1990-8.
?†††††††† Aminkeng F, Van Autreve JE, Koeleman BP, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ, Belgian Diabetes Registry (2007). TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ. Hum Immunol. 68(8):690-7. Epub 2007 Jun 11. PMID: 17678725
?†††††††† Truyen I, De Grijse J, Van Schravendijk C, De Smet D, Decochez K, Vandemeulebroucke E, Giri M, Keymeulen B, Mathieu C, Van Gaal L, De Pauw P, Weets I, Pipeleers DG, Gorus FK; Belgian Diabetes Registry (2007). Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives. Diabetologia.† PMID: 17687539
?†††††††† Van Schravendijk CF, Mirecka J. (2007). Harmonization of the bachelor-master system in the curricula of the medical doctor and the biomedical sciences. Report on a 2 days workshop. Med Teach.† 29(2-3):267-9. No abstract available. PMID: 17701646
?†††††††† van Leeuwen FW, Kros JM, Kamphorst W, van Schravendijk C, de Vos RA (2006). Molecular misreading: the occurrence of frameshift proteins in different diseases. Biochem. Soc. Trans. :738-42. PMID: 17052186
?†††††††† Truyen I, De Pauw P, Jorgensen PN, Van Schravendijk C, Ubani O, Decochez K, Vandemeulebroecke E, Weets I, Mao R, Pipeleers DG, Gorus FK, The Belgian Diabetes Registry (2005). Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes.† Diabetologia 48(11): 2322-2329.
?†††††††† Borromeo CM, Pottier X, In ít Veld P, Pipeleers-Marichal MA, Kaufman L, Pipeleers DG and Van Schravendijk CFH. (2005) Heterogeneity in distribution of amyloid- positive islets in type-2 diabetic patients. Virchows Arch 446 : 232-238.
?†††††††† Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness (2004). Dominique Delmeire, Daisy Flamez, Karen Moens, Simon A. Hinke, Chris Van Schravendijk, Daniel Pipeleers, Frans Schuit. Biochemical Pharmacology† 68 (1):33-39.
?†††††††† Karen Moens, Veerle Berger, Jung-Mo Ahn, Chris Van Schravendijk, Victor J Hruby, Daniel Pipeleers and Frans Schuit (2002) Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells. Diabetes 51 (3): 669-675.
?†††††††† Zambre Y, Van Schravendijk C, Ling Z (2001). Interleukin-1 beta inhibits proinsulin conversion in rat beta-cells via a nitric oxide-dependent pathway. Horm Metab Res. 33(11):639-44.
?†††††††† K. Hostens, D. Pavlovic, Y. Zambre, Z. Ling, C. Van Schravendijk, D.Eizirik and D. Pipeleers (1999). Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. J. Clin. Invest.104 : 67 – 72
?†††††††† K. Hostens, Z. Ling, C. Van Schravendijk and D. Pipeleers (1999). Prolonged exposure of human ? cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine. J. Clin. Endocrinol. Metab. 84 : 1386 – 1390.
?†††††††† Zambre Y, Ling Z, Chen MC, Hou X, Woon CW, Culler M, Taylor JE, Coy DH, Van Schravendijk C, Schuit F, Pipeleers DG, Eizirik DL (1999). Inhibition of human pancreatic islet insulin release by receptor-selective somatostatin analogs directed to somatostatin† receptor subtype 5. Biochem Pharmacol. 15, 57(10):1159-64.
?†††††††† Hou X, Ling Z, Quartier E, Foriers A, Schuit F, Pipeleers D, Van Schravendijk C (1999). Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors. Diabetologia 42(2): 188-194
?†††††††† Houssa P, Dinesen B, Deberg M, Frank BH, Van Schravendijk C, Sodoyez-Goffaux F, Sodoyez JC (1998). First direct assay for intact human proinsulin. Clinical Chemistry 44(7): 1514-1519
?†††††††† Keymeulen B, Ling Z, Gorus FK, Delvaux G, Bouwens L, Grupping A, Hendrieckx C, Pipeleers-Marichal M, Van Schravendijk C, Salmela K, Pipeleers DG (1998). Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 41(4): 452-459.
?†††††††† Zambre Y, Ling Z, Hou X, Foriers A, Van Den Bogaert B, Van Schravendijk C, Pipeleers D (1998). Effect of glucose on production and release of proinsulin conversion products by cultured human islets. J. Clin. Endocrinol. Metab. 83 (4): 1234-1238
?†††††††† Moens K, Flamez D, Van Schravendijk C, Ling Z, Pipeleers D, Schuit F (1998) Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors. Diabetes 47(1): 66-72.
?†††††††† Grupping AY, Cnop M, Van Schravendijk CFH, Hannaert JC, Van Berkel TJ, Pipeleers DG (1997). Low density lipoprotein binding and uptake by human and rat islet beta cells. Endocrinology 138 (10): 4064-4068
?†††††††† Hou X, Ling Z, Zambre Y, Foriers A, Houssa P, Deberg M, Sodoyez JC, Hales CN, Van der Auwera BJ, Pipeleers D, Van Schravendijk C (1997). Proinsulin and its conversion intermediates in human pancreas and isolated islet tissue: kinetics and steady-state analysis. Pancreas 15(2): 113-121
?†††††††† Semakula C., Vandewalle C.L., Van Schravendijk C.F.H., Sodoyez J.C., Schuit, F.C., Foriers A., Falorni A., Craen M., Decraene P., Pipeleers D.G., Gorus F.K., and the Belgian Diabetes Registry (1996). Abnormal circulating pancreatic enzyme activities in more than twenty-five percent of recent-onset insulin-dependent diabetic patients: association of hyperlipasemia with high titer islet cell antibodies. Pancreas 12 (4) : 321-33
?†††††††† De Bleser P.J., Jannes P., Van Buul-Offers S.C., Hoogerbrugge C.M., Van Schravendijk C.F.H., Niki T., Rogiers V., Van den Brande J.L., Wisse E., Geerts A. (1995). Insulin-like growth factor-II/Mannose 6-phosphate receptor is expressed on CCL4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-? in cocultures with sinusoidal endothelial cells. Hepatology 21 : 1429 – 1437.
?†††††††† C.F.H. Van Schravendijk, R. Kiekens, L. Heylen and D.G. Pipeleers (1994). Amino-acid responsiveness in beta cell subpopulations with different sensitivity to glucose . Biochem. Biophys. Res. Commun. 204 (2) 490-497.
?†††††††† F.K. Gorus, J.C. Sodoyez, D.G. Pipeleers, B. Keymeulen, A. Foriers, C.F.H. Van Schravendijk (1992). Detection of high-affinity autoantibodies against islet amyloid polypeptide in human serum. Lack of association with type 1 (insulin-dependent) diabetes, type 2 (non-insulin-dependent) diabetes or ageing (1992). Study of the Belgian Diabetes Registry. Diabetologia 35 : 1080-1086.
?†††††††† C.F.H. Van Schravendijk, R. Kiekens and D. G. Pipeleers (1992). Pancreatic b-Cell Heterogeneity in Glucose-induced Insulin Secretion. J. Biol. Chem. 267 : 21344-21348.
?†††††††† C.F.H. Van Schravendijk, L. Heylen, J.L. Van den Brande and D. Pipeleers (1990). Direct effect of insulin and IGF-I on the secretory activity of rat pancreatic B-cells. Diabetologia 33 : 649-653.
?†††††††† C.F.H. Van Schravendijk, A. Foriers, J.L. Van den Brande and D. Pipeleers (1987).† Evidence for the Presence of Type-I Insulin-Like Growth Factor Receptors on Pancreatic Islet Cells. Endocrinology 121 : 1784-1788.
?†††††††† C.F.H. Van Schravendijk, E. Hooghe-Peters, J.L. Van den Brande and D. Pipeleers† (1986).†† Receptors for Insulin-Like Growth Factors and Insulin on Murine Fetal Cortical Brain Cells.† Biochem. Biophys. Res. Commun. 135 : 228-238.
?†††††††† D.G. Pipeleers, F. Gorus, F. Schuit, M. Van De Winkel, C. Van Schravendijk, P. In’t Veld and W. Gepts (1986).† Islet Cell Interrelationships and Insulin Release.† In : Diabetes 1985 (M. Serriano-Rios and P.J. LefËbvre, eds) Elsevier, Amsterdam pp155-158.
?†††††††† D.G. Pipeleers, F. Schuit, C. Van Schravendijk and M. Van De Winkel.† Interplay of Nutrients and Hormones in the Regulation of Glucagon Release (1985).† Endocrinology 117 : 817-823.
?†††††††† C.F.H. Van Schravendijk, A. Foriers, E. Hooghe-Peters, V. Rogiers , P. De Meyts, J.C. Sodoyez and D. Pipeleers (1985). Pancreatic Hormone Receptors on Islet Cells.† Endocrinology 117 :† 841-848.
?†††††††† C.F.H. Van Schravendijk, E. Hooghe-Peters, P. De Meyts and D. Pipeleers (1984).† Identification and Characterization of Insulin Receptors on Foetal-Mouse Brain-Cortical Cells.† Biochem. J. 220 : 165-172.