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Professor Dr. Seppo Meri CV


Professor Dr. Seppo Meri

Professor Meri, Seppo Kalevi MD, PhD, brief CV
Head of the Haartman Institute,
Professor of Immunology, Dept of Bacteriology and Immunology,
University of Helsinki and Helsinki University Central Hospital
E-mail: seppo.meri(at)helsinki.fi
Internet: www.hi.helsinki.fi/complement





Date and place of birth: July 1, 1957, Kerimäki, Finland

Education and training:
1984 M.D. and Licentiate in Medicine, Univ of Helsinki
1987 Doctor of Medical Sciences (PhD), University of Helsinki
1989 Diploma in Tropical Medicine and Hygiene, University of London
1991 Docent in Immunology, University of Helsinki
1996 Specialist in Clinical Microbiology

Professional research appointments:
1984-1996 Researcher, Dept of Bact. and Immunol., Univ Helsinki 1988 Postdoctoral fellow, University of Texas Health Science Ctr
1989-1990 EMBO long term fellowship, MRC, Cambridge, England 1997-2001 Acting Professor of Immunology, Univ Helsinki 2001-2002Fellow of the Academy of Finland 2003- Professor of Immunology, Univ Helsinki

Honorary positions
Chairman of The Finnish Society for Immunology (1999-2001)
President of The Scandinavian Society for Immunology (2001-2007)
President of The European Complement Network (2001-2003)
Board of the International Union of Immunological Societies 2004-
Board of the Helsinki Biomedical Graduate School 1997-2005
Chairman of the Doctoral Committee of the University of Helsinki, 2001-2007

Editor of journals
Scand. J. Immunol, Associate Editor 2001- ; Journal of Immunology, Associate Editor 2001-2005, Annals of Medicine, Editor 2002- ; Member of the Editorial Board: Molecular Immunology, Current Immunology Reviews, BMC Immunology, Clinical and Experimental Immunology, Journal of Autoimmunity, Autoimmunity Reviews

Other academic and professional merits and activities
Ad hoc-referee for > 20 scientific journals
Referee for Centers of Excellence, Clinical Medicine in Norway, 2003; Medical Faculty, Tartu, Estonia, XI/2001; Centers of Excellence in Estonia, 2005 (Estonian Research Council); Centers of Excellence in Norway, 2006
Referee for Professorship: 9 times
Referee for Doctorship in Medical Sciences: A total of 20, of which 3 abroad
Official Dissertation Opponent: total: 15 of which 7 abroad
Organizer of International Meetings:
Bioscience Days-Haartman Symposium, 9/1997, Organizer and Chairman
7th European Meeting on Complement in Human Disease, 6/1999; Meeting President
25th Anniversary Meeting of the Finnish Society for Immunology, 11/1999; Organizer and Chairman
Proteomics 2000, Bioscience Meeting, 2/2000, Organizer and Chairman
31st Meeting of the Scandinavian Society for Immunology, 8/2000, Meeting President
Member of the Scientific Committee for the International Congress of Immunology
(Stockholm, VIII/2001), Moderator of the Innate Immunity Section
36th joint meeting German and Scandinavian Societies for Immunology, Kiel, 2005
(President of the Scientific Committee, SSI and Chairman, Organizing Committee, SSI)
European Congress of Immunology Meeting, Paris, 2006 (16th EFIS), Steering Committee and
Scientific committee (>5000 participants)
Supervisor of PhD thesis: 19 completed, 2 due in 2007, 8 ongoing
Supervisor for 8 postdoctoral research fellows
Tutor for 32 medical students during their part-time research projects

Selected Publications
Jarva H, Janulczyk R, Hellwage J, Zipfel PF, Björck L, Meri S. Streptococcus pneumoniae evades complement attack and opsonophgocytosis by expressing the pspC-locus encoded Hic-protein that binds to short consensus repeats 8-11 of factor H. J Immunol, 168: 1880-94, 2002
Alitalo A, Meri T, Lankinen H, Seppälä IJT, Lahdenne P, Hefty PS, Akins D & Meri S. Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J Immunol, 169: 3847-53, 2002
Hellwage J, Jokiranta TS, Friese MA, Wolk TU, Kampen E, Zipfel PF, Meri S. Recognition of complement C3b/C3d and cell surface polyanions by overlapping binding sites on the most carboxy-terminal domain 20 of complement factor H. J Immunol, 169:6935-44, 2002
Oksjoki R, Jarva H, Kovanen PT, Laine P, Meri S, Pentikainen MO. Association between complement factor H and proteoglycans in early human coronary atherosclerotic lesions: implications for local regulation of complement activation. Arterioscl Thromb Vasc Biol, 23:630-6, 2003
Manuelian T, Hellwage J, Meri S, Caprioli J, Noris M, Neumann HPH, Remuzzi G, Zipfel PF. Factor H gene mutations in hemolytic uremic syndrome: single amino acid exchanges reduce binding affinity to C3b/C3d, heparin and surface attachment to endothelial cells. J Clin Invest, 111: 1181-90, 2003
Jarva H, Hellwage J, Jokiranta TS, Lehtinen M, Zipfel PF, Meri S. The group B streptococcal beta and pneumococcal Hic proteins are structurally related immune evasion molecules that bind the complement inhibitor factor H in an analogous fashion. J Immunol, 172: 3111-8, 2004.
Alitalo A, Meri T, Chen T, Lankinen H, Cheng ZZ, Jokiranta S, Seppälä I, Lahdenne P, Hefty PS, Akins DR, and Meri S. Lysine-dependent Multi-point Binding of the Borrelia burgdorferi Virulence Factor OspE to the C-terminus of Factor H. J Immunol, 2004, 172: 6195-6201
Jarva H, Ram S, Vogel U, Blom AM, Meri S. Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis, J Immunol, 174:6299-6307, 2005
Jokiranta TS, Jaakola VP, Lehtinen MJ, Pärepalo M, Meri S, and Goldman A. Structure of Complement Factor H C-terminus Reveals Molecular Basis of Atypical Hemolytic Uremic Syndrome. EMBO J, 25: 1784-94, 2006
Laine M, Jarva H, Seitsonen S, Haapasalo K, Lehtinen MJ, Lindeman N, Anderson DH, Johnson PT, Järvelä I, Jokiranta TS, Hageman GS, Immonen I and Meri S. Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein. J Immunol, 178:3831-6, 2007


He became ORPHEUS Executive Committee member February 9, 2007.    By decision of Zagreb City Office for General Administration January 26, 2012, the mandate of Seppo Kalevi Meri, as legal representative of ORPHEUS, will finish in 2014. Decision was accepted by General Assembly, Bergen 2012