Univ.-Prof. Dipl.-Ing. Dr. Hannes Stockinger
Dean of Doctoral School, Medical University of Vienna; Internet: http://www.meduniwien.ac.at/phd;
Chairman Department of Molecular Immunology, Center of Physiology, Pathophysiology and Immunology, Medical University of Vienna; Internet: http://www.meduniwien.ac.at/immunology;
CEO Competence Center Biomolecular Therapeutics, Internet: http://www.bmt-research.at
Business address†††††††† A-1090 Vienna, Lazarettgasse 19, Austria
Tel.: +43-1-40160 33001; Fax: +43-1-40160 933002;
E-mail: hannes.stockinger(at) meduniwien.ac.at
Date of Birth: May 8, 1955, Nationality:†† Austrian, Marital status: Married.
1975-1982†††††††† University of Natural Resources and Applied Life Sciences Vienna, Field of study: Biotechnology
1982†††† Biotechnology diploma University of Natural Resources and Applied Life Sciences Vienna, Austria
1982-1985†††††††† Postgraduate training and PhD thesis at the Institute of Immunology, University of Vienna, and the Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences Vienna, Austria
1985†††† PhD (Dr. rer. nat. tech.) University of Natural Resources and Applied Life Sciences Vienna, Austria
1985-1989†††††††† Research Associate, Inst. Immunology, Univ. Vienna, Austria
1989-1991†††††††† Assistant Professor, University of Vienna, Austria
1991†††† Appointment as university lecturer (Univ.-Doz.), University of Vienna, Austria
1991-1997†††††††† Associate Professor, University of Vienna, Austria
1997-2004†††††††† Ao. University Professor, University of Vienna, Austria
1999-2004†††††††† Deputy-chairman of the Institute of Immunology, University of Vienna
2004-present†††† Appointment as Full University Professor for Molecular Immunology, Medical University of Vienna, Austria
2004-present†††† Chairman of the Department of Molecular Immunology, Medical University of Vienna, Austria
2004-present†††† Dean of the Doctoral School of the Medical University Vienna
2008-present†††† Deputy chairman Center of Physiology, Pathophysiology and Immunology, Medical University Vienna
1986-1988†††††††† Treasurer of the Collegium Immunologicum Vindobonense
1992-1994†††††††† Vice Secretary of the Austrian Society for Allergology and Immunology
1994-1996†††††††† Secretary General of the Austrian Society for Allergology and Immunology
1996-1997†††††††† Council member of the Austrian Society for Allergology and Immunology
1997-2002†††††††† Member of the Managing Board of the European Confederation of Laboratory Medicine
1997-2007†††††††† Member of the Editorial Board of International Archives of Allergy and Immunology
2000-2002†††††††† President-elect of the Austrian Society for Allergology and Immunology
2000-2004†††††††† Member of the International Advisory Board of Russian Journal of Immunology
2000-2006†††††††† Advisory Board member of Signal Transduction ñ Receptors, Mediators, Genes.
2002-2004†††††††† President of the Austrian Society for Allergology and Immunology
2004-2006†††††††† Past-president of the Austrian Society for Allergology and Immunology
1995-present†††† Member of the Clinical Immunology Group of the European Federation of Immunological Societies (EFIS-CIG)
2002-present†††† CEO Competence Center for Biomolecular Therapeutics Research Vienna
2003-present†††† Executive editor of Immunology Letters
2004-present†††† Member of the Human Cell Differentiation Molecules Council
2005-present†††† Board member of the Austrian Science Fund
2006-present†††† Treasurer of the European Federation of Immunological Societies (EFIS)
2007-present†††† Treasurer of the Federation of Austrian Scientific Societies
2009-present†††† Editor Journal of Biomedicine and Biotechnology
2009-present†††† Executive Committee member of ORPHEUS (Organization for PhD Education in Biomedicine and Health Sciences in the European System)
More than 140 publications in scientific journals including the top journals Cell, Science, Nature Methods, Journal of Experimental Medicine that were cited more than 5000x.
Five patents in the field of immunomodulation
Immunology with emphasis on the structure and function of surface receptors on T cells and accessory/dendritic cells to identify novel targets for influencing abnormal and unwanted immune reactions in immunological disorders and diseases. Internationally well recognized are the investigations, which contribute to the understanding of how glycosylphosphatidylinositol (GPI)-anchored receptor proteins transduce signals across the plasma membrane. These studies were fundamental for the identification and characterization of special membrane microdomains, called lipid rafts, which are more and more believed to control initiation of signal transduction across the membrane of cells.
Current Research Emphasis
Characterization of novel co-regulatory molecules of T cells and the underlying signal transduction mechanisms to design and develop strategies to distinguish and correct aberrant and unwanted reaction of immune cells in immunological diseases. Special emphasis is on the development of novel microscopic techniques to analyze the dynamic of receptors and signaling molecules on the single molecule level in living cells in real time. First results derived from this ìreal-time biochemistry with single molecules in living cellsî suggest a new vista of how molecules function in cells. Based on these studies new diagnostic assays will be developed.
Ten Selected Publications
1.†††††††† Stockinger, H., S. J. Gadd, R. Eher, O. Majdic, W. Schreiber, W. Kasinrerk, B. Strass, E. Schnabl, and W. Knapp. 1990. Molecular characterization and functional analysis of the leukocyte surface protein CD31. J.Immunol. 145: 3889.
2.†††††††† Stefanov·, I., V. HorejsÌ, I. J. Ansotegui, W. Knapp, and H. Stockinger. 1991. GPI-anchored cell surface molecules complexed to protein tyrosine kinases. Science 254: 1016.
3.†††††††† Kasinrerk, W., T. Baumruker, O. Majdic, W. Knapp, and H. Stockinger. 1993. CD1 molecule expression on human monocytes induced by granulocyte-macrophage colony stimulating factor. J. Immunol.† 150: 579.
4.†††††††† Bohuslav, J., V. Horejsi, C. Hansmann, J. Stˆckl, U. H. Weidle, O. Majdic, I. Bartke, W. Knapp, and H. Stockinger. 1995. Urokinase plasminogen activator receptor, b2-integrins, and Src-kinases within a single receptor complex of human monocytes. J.Exp.Med. 181:1381.
5.†††††††† Prager, E., R. Sunder-Plassmann, C. Hansmann, C. Koch, W. Holter, W. Knapp, and H. Stockinger. 1996. Interaction of CD31 with a heterophilic counterreceptor involved in downregulation of human T cell responses. J. Exp. Med. 184:41.
6.†††††††† Prager, E., G. Staffler, O. Majdic, M. D. S‰emann, S. God·r, G. J. Zlabinger, and H. Stockinger. 2001. Induction of hyporesponsiveness and impaired T lymphocyte activation by the CD31 receptor:ligand pathway in T cells. J. Immunol. 166: 2364.
7.†††††††† Staffler, G., A. Szekeres, G.J. Sch¸tz, M.D. S‰emann, E. Prager, M. Zeyda, K. Drbal, G.J. Zlabinger, T. Stulnig, and H. Stockinger. 2003. Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts. J. Immunol. 171:1707.
8.†††††††† Leksa, V., S. Godar, H. B. Schiller, E. Fuertbauer, A. Muhammad, K. Slezakova, V. Horejsi, P. Steinlein, U. H. Weidle, B. R. Binder, and H. Stockinger. 2005. TGF-beta induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen. J Cell Sci 11:4577.
9.†††††††† Schwarzenbacher, M., M. Kaltenbrunner, M. Brameshuber, C. Hesch, W. Paster, J. Weghuber, B. Heise, A. Sonnleitner, H. Stockinger*, and G.J. Sch¸tz*. 2008. Micropatterning for quantitative analysis of protein-protein interactions in living cells. Nature Meth. 5: 1053. *Corresponding author.
10.†††††† Paster, W., C. Paar, P. Eckerstorfer, A. Jakober, K. Drbal, G.J. Sch¸tz, A. Sonnleitner, and H. Stockinger. 2009. Genetically encoded FRET-sensors for the conformation of the Src-family kinase Lck. J. Immunol. 182: 2160.
He become ORPHEUS Executive Committee member† April 24, 2009.